Association between Intercanine Width and Mandibular Dental Arch Forms.

A descriptive cross-sectional study was conducted to investigate the association between intercanine width and the mandibular arch form in 109 dentate subjects, who visited Orthodontics Department from October 2018 to December 2019. Using Vernier caliper, the intercanine width was measured as the distance between the left and right canines on each cast with the arch form, also categorized as tapered, square or ovoid, using predefined criteria. Spearman's rank correlation demonstrated highly significant association between intercanine width and mandibular dental arch forms, with p value of 0.005. Key Words: Dentate subjects, Mandibular arch forms, Inter-canine width, Sexual dimorphism, Mandibular dental cast.

Association of Gonial Angle on Panoramic Radiograph with the Facial Divergence on Lateral Cephalogram.

OBJECTIVE: To find the mean gonial angle values among different facial divergent cases. STUDY DESIGN: Cross-sectional descriptive study. PLACE AND DURATION OF STUDY: Karachi Medical and Dental College from October 2018 to December 2019. METHODOLOGY: Panoramic radiographs (OPG) and lateral cephalograms of 91 patients, 33 males and 58 females, were obtained. Sella-Nasion-Mandibular Plane (SNMP) angle was measured on lateral cephalogram and gonial angles were measured on panoramic radiograph. Subjects were divided into three groups as per SNMP angle as hypodivergent, normodivergent and hyperdivergent. A p-value of less than 0.05 was considered statistically significant. RESULTS: The mean value of the gonial angle in OPG among all the patients was 125.05° with a standard deviation 7.24°. The average gonial angle in males was 124.10° ±5.67° and in females was 125.59° ±7.99°. Out of 91 patients, 14 were hypodivergent, 28 were normodivergent and 49 were hyperdivergent. The mean values of gonial angle among these three groups were 119.77° ±6.05°, 123.66° ±5.50° and 127.36° ±7.52°. One-way ANOVA demonstrated highly significant differences in the values of gonial angles among three facial divergences (p=0.001). Post-Hoc Tukey analysis showed that there was a significant difference between gonial angle of hyperdivergent and hypodivergent cases (p=0.001). CONCLUSION: Gonial angle on panoramic radiographs (OPG) may provide useful knowledge about the facial divergence of the orthodontic patients. Key Words: Gonial angle, Facial divergence, Lateral cephalogram, Panoramic radiograph, Orthodontic diagnosis.

Role of Salivary Biomarkers in Detection of Cardiovascular Diseases (CVD).

Human whole mouth saliva (WMS) is secreted by salivary glands, namely parotid, submandibular/sublingual and other minor glands of the oral cavity. It is secreted in a systematic way, and contain informative proteins and peptides for the early detection of contagious diseases and organ-related diseases. The role of WMS as a liquid biopsy for the detection of cardiovascular diseases (CVD) through Myoglobin (MYO), Cardiac troponin I (cTnI), Creatine phosphokinase MB (CK-MB), Myeloperoxidase (MPO), brain natriuretic peptide (NT-proBNP), Exosomal miRNA, C-Reactive Protein (CRP), Matrix metalloproteinase-8 (MMP-8), MMP-9 and tissue inhibitor of MMP-8 (TIMP-1), leukotriene B4 has been well reported in last decade, that have been reviewed in the literature comprehensively below.